SR-121463A  185913-79-5

價格:1000元/公斤 含量:99% 包裝:25公斤
CAS;185913-79-5
分子式：C17H22ClNO3
分子量：323.8228
化學名稱 N-tert-Butyl-4-[5'-ethoxy-4-[2-(4-morpholinyl)ethoxy]-2'-oxospiro[cyclohexane-1,3'-indolin]-1'-ylsulfonyl]-3-methoxybenzamide fumarate
The reduction of diethyl 3-(methoxymethoxy)glutarate (I) with LiAlH4 in THF gives 3-(methoxymethoxy)pentane-1,5-diol (II), which is treated with Ts-OH and TEA in THF to yield the disulfonate (III). The condensation of (III) with 5-ethoxyindolin-2-one (IV) by means of tBu-OK in THF affords the spiro compound (V), which is deprotected with HCl in methanol to afford the spiranic alcohol (VI). The oxidation of (VI) with pyridinium chlorochromate (PCC) over Al2O3 provides the spiranic cyclohexanone (VII), which is treated with 2-chloroethanol (VIII) and Ms-OH in toluene to give the ketal (IX). The reaction of (IX) with zinc borohydride and trimethylsilyl chloride in ethyl ether/dichloromethane yields the 2-chloroethoxy derivative (X), which is condensed with 4-(N-tert-butylcarbamoyl)-2-methoxybenzenesulfonyl chloride (XI) by means of tBu-OK in THF to afford the adduct (XII). Finally, the target compound is obtained by condensation of (XII) with morpholine (XIII) by means of NaI in DMF, followed by treatment with fumaric acid.

16359-54-9    C12H17ClN2       185913-79-5   C17H22ClNO3
402856-42-2   C17H23Cl2NO      65527-62-0    C21H27N3O
8378-23-2     C12H17NO         1099-87-2     C19H27NaO5S
99918-43-1    C11H18Cl2N2      1445566-01-7  C13H17NO
6740-85-8     C12H13ClO        1445583-20-9  C18H26N4O2
14461-91-7    C12H12N2O2       612526-40-6   C17H12BrFN4
39243-02-2    C16H12BrN5       40054-69-1    C17H15ClN4S
5650-44-2     C10H13NO         39742-60-4    C13H17NO
13956-29-1    C21H30O2         4021-34-5     C17H26N2O
2426-63-3     C17H27ClN2O      1364933-55-0  C23H22N2O
2894-68-0     C16H12Cl2N2O     39243-02-2    C16H12BrN5
67579-76-4    C18H26Cl2N2O     33643-46-8    C13H16ClNO
77872-41-4    C13H18N2O        28910-91-0    C17H12ClFN4 
141-78-6      C4H8O2           87-90-1       C3Cl3N3O3
13415-55-9    C18H22O2         5485-65-4     C15H22ClNO
776994-64-0   C17H23NO3        21409-26-7    C19H24N2
13415-59-3    C16H24ClNO       2687-91-4     C6H11NO
79-41-4       C4H6O2           23022-83-5    C9H9BrO
2114-00-3     C9H9BrO          49656-78-2    C10H14ClNO
936-59-4      C9H9ClO          93-55-0       C9H10O